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Schematic drawing of D1R movement. D1R randomly diffuses in the plasma membrane and can physically interact with NMDA receptors (NMDA-R), which have undergone an allosteric change, due to ligand occupation of the NMDA/glutamate-binding site. Formation of a D1R–NMDA receptor complex reduces D1R mobility. When the NMDA receptor is anchored to postsynaptic density, movement is arrested.
