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. 2006 Jan 9;103(3):720–725. doi: 10.1073/pnas.0507631103

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Copyright © 2006, The National Academy of Sciences

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Fig. 5. — Generation and analyses of HBZ-transgenic (Tg) mice. (A) Schematic representation of the HBZ transgene. The promoter (Prom) and enhancer (Enh) of the mouse CD4 (mCD4) gene were ligated to HBZ cDNA (including the 5′ UTR) plus the polyadenylation signal sequence of SV40. Expression of HBZ transcripts was detected by RT-PCR in purified CD4⁺ splenocytes from HBZ-Tg mice. (B) T cell subsets in HBZ-Tg mice. Values are means ± SD from five transgenic mice. **, P < 0.01. (C) Proliferative responses of thymocytes from HBZ-Tg mice to IL-2 and/or stimulation with an anti-CD3 antibody. Proliferative responses were measured by ³H-thymidine incorporation. ³H-thymidine uptake of thymocytes without anti-CD3 antibody and IL-2 was 5.8 ± 4.6 cpm for control mice and 21.0 ± 16.0 cpm for HBZ transgenic mice. Values are means ± SD in triplicate. *, P < 0.05; **, P < 0.01.