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Alignment of the amino acid sequences of the N-terminal regions of α-spectrins. Shown are the alignment of a structurally well defined and functionally essential region of α-spectrin, namely the N-terminal helix that binds β-spectrin and the first full triple-helical repeat. The secondary structure elements are assigned by alignment with the NMR structure of human αI-spectrin (Protein Data Bank ID code 1OWA).
