Table 1. Cardiac function in WT and RyR2-S2808A mice at 4 weeks after MI.
| WT (20) | S2808A (17) | |
|---|---|---|
| Age, months | 5.0 ± 0.3 | 4.8 ± 0.3 |
| Body weight, g | 24.99 ± 0.67 | 25.11 ± 0.89 |
| Infarct size, % | 36.50 ± 3.10 | 36.05 ± 3.27 |
| HW/BW ratio | 7.65 ± 0.39 | 8.32 ± 0.43 |
| Echocardiography | ||
| Ejection fraction, % | 33.76 ± 3.67 | 50.43 ± 3.29* |
| Fractional shortening, % | 14.86 ± 1.93 | 22.73 ± 2.00** |
| Stroke volume, μl | 87.6 ± 0.74 | 112.6 ± 0.75* |
| LVPW, mm | 0.84 ± 0.01 | 0.78 ± 0.02** |
| EDD, mm | 5.21 ± 0.13 | 4.70 ± 0.13* |
| ESD, mm | 3.98 ± 0.16 | 3.51 ± 0.15* |
| Cardiac catheterization | ||
| dP/dt, mmHg/s | 5,641 ± 304 | 6,810 ± 397* |
| -dP/dt, mmHg/s | -4,804 ± 275 | -5,917 ± 412* |
| MAP | 75.85 ± 2.30 | 80.30 ± 3.91 |
Analysis of in vivo cardiac size and function by echocardiography and cardiac catheterization in wild-type and RyR2-S2808A mice. Number in parentheses represents number of mice. LVPW, left ventricular posterior wall thickness; EDD, end-diastolic diameter; ESD, end-systolic diameter; dP/dt, slope of the maximal derivative of change in pressure over time; -dP/dt, slope of the maximal negative derivative of change in pressure over time; MAP, mean arterial blood pressure. *, P < 0.05; **, P < 0.01.