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. 2026 Jun 22;98(26):19603–19614. doi: 10.1021/acs.analchem.6c01280

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© 2026 The Authors. Published by American Chemical Society

This article is licensed under CC-BY 4.0

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Plasma sEV proteomes reflect the purification approach. Five replicates (n = 5) were analyzed per condition. Average number of (A) peptides and (B) protein groups identified following ultracentrifugation (UC), size exclusion chromatography with ultrafiltration (SECUF), and polymer precipitation (PPT). (C) UpSet plot displaying the overlap in protein groups detected in each of the conditions. (D) Principal component analysis and (E) hierarchical clustering analysis illustrating the difference among UC, SECUF, and PPT sEVs.