Table II. Progression of MPD in NUP98–HOXA9 hemopoietic chimeras.
Femur |
Spleen |
||||
---|---|---|---|---|---|
NCa × 107 | CFCb × 103 | Size (g) | NCa × 107 | CFCb × 103 | |
NUP98–HOXA9 | |||||
Early post-BMTc (n = 3) | 1.6 ± 0.3 | 110 ± 18 | 0.15 ± 0.06 | 10 ± 1 | 19 ± 8 |
Late post-BMTd (n = 2) | 2.3 ± 0.4 | 64 ± 26 | 0.38 ± 0.08 | 30 ± 5 | 150 ± 10 |
Secondary BMTe (n = 2) | 4.3 ± 0.4 | 770 ± 170 | 0.37 ± 0.20 | 68 ± 42 | 1100 ± 53 |
EGFP controlf (n = 3) | 2.1 ± 0.1 | 60 ± 24 | 0.10 ± 0.01 | 13 ± 3 | 5.1 ± 1 |
aNucleated cells.
bMyeloid colony forming cells, as measured in progenitor assays.
cTwo months post-BMT.
dEight months post-BMT.
eTransplanted with 106 BM cells from early post-BMT group, sacrificed at 5 months.
fOne mouse early, and two mice late post-BMT, pooled because identical.