Table 2.
Distribution of hippocampal volume, fractional anisotropy (FA) and cerebral blood flow (CBF) at Year 30 and cumulative exposure to cannabis in ‘cannabis-years’ among 648 CARDIA participants at the Year 30 MRI sub-study, excluding participants with a history of stroke or TIA.
| NEVER TOBACCO SMOKING | All (340) | Never user | Ever Cannabis Usea | ||
|---|---|---|---|---|---|
| 1 day to 0.5 cannabis years | 0.5 to < 2 cannabis years | > 2 cannabis years | |||
| Volume Hippocampus (mm3), mean (SD) | 3836 (413) | 3800 (425) | 3803 (421) | 3919 (338) | 3950 (445) |
| FA Fornix, mean (SD) | 0.266 (0.035) | 0.273 (0.034) | 0.263 (0.036) | 0.271 (0.036) | 0.259 (0.031) |
| CBF Hippocampus (ml/100 g/min), mean (SD) | 41.781 (9.941) | 42.898 (10.397) | 42.292 (8.773) | 38.903 (10.091) | 41.291 (13.332) |
| EVER TOBACCO SMOKING | All (308) | Never user | Ever Cannabis Usea | ||
| 1 day to 0.5 cannabis years | 0.5 to < 2 cannabis years | > 2 cannabis years | |||
| Volume Hippocampus (mm3), mean (SD) | 3749 (397) | 3652 (496) | 3714 (390) | 3789 (395) | 3766 (384) |
| FA Fornix, mean (SD) | 0.262 (0.036) | 0.258 (0.023) | 0.260 (0.036) | 0.270 (0.036) | 0.257 (0.038) |
| CBF Hippocampus (ml/100 g/min), mean (SD) | 42.172 (8.770) | 44.944 (6.835) | 42.187 (9.112) | 40.629 (7.705) | 43.042 (9.879) |
Stratified by ever tobacco smoking.
FA fractional anisotropy, CBF cerebral blood flow, CARDIA coronary artery risk development in young adults study, N number of participants; +-SD standard deviation.
aSelf-reported cumulative exposure to cannabis in cannabis-years; 1 cannabis-year of exposure = 365 days of cannabis use (1 year × 365 days/y).