Table 1.

Guiding principles for DOC hub development. Table repurposed from ref⁶⁷.

Desirable Property	Suggested Hub Design Element
Orthogonal Reactive Centers	Include multiple, distinct functional groups (e.g., azides, sulfonyl fluorides, phosphoramidofluoridates) that do not cross-react to ensure clean chemical transformations.
Chemoselectivity	S/P─F bonds should be sufficiently electrophilic for substitution but balanced to avoid uncontrolled or side reactions. Ideally, S/P─F bonds should only be activated by the correct catalyst/reagent combinations.
Click Group Stability	Click groups should be stable to various synthetic conditions, allowing early integration in DOC sequences. Ensure hubs can withstand typical laboratory and storage conditions, including common solvents.
Predictable Regioselectivity	Click reactions should generate a single product regioisomer.
Facile Access and Scalability	Hubs should be synthesized from readily accessible materials using scalable methods to promote community adoption and ease of use.
Low Volatility	Prioritize to minimize exposure risks and ensure ease of handling.
Quenchable	Safe quenching of the electrophilic bonds using simple procedures (e.g., soaking overnight in isopropanol/sodium hydroxide).