Table 1.
Characteristics of participants at baseline and post-intervention of a 60-day nicotinamide mononucleotide supplementation (N = 80)
| Baseline | Post-intervention | |
|---|---|---|
| Age, year | 49.4 ± 6.8 | - |
| Female, n | 47 | - |
| Weight, kg | 67.1 ± 11.7 | - |
| Height, cm | 157.4 ± 9.1 | - |
| BMI, kg/m2 | 27.1 ± 4.1 | - |
| NAD, nmol/L | 7.21 [5.5, 10.6] | 34.6 [18.3, 46.1] |
| Complete blood count | ||
| WBC, 109/L | 7.07 ± 1.70 | 7.69 ± 2.26 |
| Neutrophils, % | 57.7 [51.9, 62.8] | 53.7 [47.6, 59.42] |
| Lymphocytes, % | 35.6 ± 6.83 | 37.25 ± 7.09 |
| Monocytes, % | 3.6 [2.9, 4.4] | 5.25 [4.4, 6.23] |
| Eosinophils, % | 2.7 [1.78, 4.58] | 2.85 [1.98, 5.22] |
| Absolute neutrophils, 109/L | 4.06 ± 1.28 | 4.12 ± 1.43 |
| RBC, 1012/L | 4.68 ± 0.62 | 4.79 ± 0.68 |
| Hemoglobin, g/dL | 13.3 ± 1.84 | 13.57 ± 2.01 |
| MCHC, g/dL | 33.3 [32.5, 33.9] | 32.5 [31.7, 33.2] |
| MCV, fL | 86.3 ± 9.60 | 88.3 ± 10.2 |
| Platelet count, 109/L | 286 ± 74.9 | 314 ± 81.2 |
| Liver function | ||
| ALP, U/L | 85.4 [67.2, 103] | 88.8 [73.6, 111] |
| ALT, U/L | 19.4 [13.7, 26.6] | 17.4 [13.4, 24.2] |
| AST, U/L | 22.2 [17.6, 25.7] | 20.9 [17.5, 24.8] |
| Total bilirubin, mg/dL | 0.44 [0.36, 0.65] | 0.52 [0.37, 0.71] |
| Kidney function | ||
| BUN, mg/dL | 8.7 ± 2.75 | 8.99 ± 2.6 |
| GFR, mL/min/1.73 sqm | 103 ± 19.8 | 96.08 ± 20.61 |
| Creatinine, mg/dL | 0.7 [0.65, 0.85] | 0.76 [0.66, 0.95] |
| Urea, mg/dL | 18.6 ± 5.89 | 19.28 ± 5.52 |
| Uric acid, mg/dL | 5.1 [4.4, 5.9] | 5.1 [4, 5.82] |
| Lipid profile | ||
| HDL, mg/dL | 41.6 [36.7, 47.4] | 43.5 [39.0, 50.9] |
| LDL, mg/dL | 120 [102, 138] | 127 [109, 146] |
| Triglycerides, mg/dL | 148 [110, 201] | 130 [100, 175] |
| Total cholesterol, mg/dL | 182 [153.9, 198.7] | 180.4 [159.5, 204.9] |
| Electrolyte and minerals | ||
| Calcium, mg/dL | 9.3 [9.0, 9.5] | 9.4 [9.2, 9.8] |
| Chloride, mmol/L | 101.1 [99.6, 102.9] | 101.4 [100.1, 103.1] |
| Sodium, mmol/L | 139 [138, 141] | 140 [139, 142] |
| Potassium, mmol/L | 4.3 [4.07, 4.6] | 4.6 [4.3, 4.8] |
| Protein | ||
| Albumin, g/dL | 4.38 ± 0.28 | 4.41 ± 0.34 |
| Total protein, g/dL | 7.1 [6.9, 7.4] | 7.6 [7.2, 7.9] |
| Coagulation | ||
| aPTT, second | 32.35 [30.37, 35.52] | 32.2 [29.3, 34.8] |
| PT, second | 11.7 [11.47, 12.01] | 11.9 [11.4, 12.3] |
Data are presented as mean ± SD for normally distributed variables or median [IQR] for skewed distributed variables unless otherwise indicated
ALP, alkaline phosphatase; ALT, alanine transaminase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; BUN, blood urea nitrogen; GFR, glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MCHC, mean corpuscular hemoglobin concentration; MVC, mean corpuscular volume; NAD, nicotinamide adenine dinucleotide; PT, patient prothrombin time; PVC, packed cell volume; RBC, red blood cell; WBC, white blood cell