Table 2.
The association of baseline blood nicotinamide adenine dinucleotide baseline level expressed as 1 nM higher level and baseline blood laboratory parameters
| B-value | 95% CIs | p-value | |
|---|---|---|---|
| Complete blood count | |||
| Absolute neutrophils, count/cmm* | − 0.008 | − 0.017–0.001 | 0.099 |
| Eosinophils, %* | 0.012 | − 0.008–0.032 | 0.223 |
| Hemoglobin, g/dL | 0.012 | − 0.043–0.067 | 0.665 |
| Lymphocytes, % | 0.24 | 0.047–0.439 | 0.017 |
| Monocytes, %* | 0.008 | − 0.003–0.018 | 0.140 |
| Neutrophils, % | − 0.36 | − 0.57 to − 0.14 | 0.002 |
| Platelet count, 109/L | − 4.42 | − 2233 to 2224 | 0.997 |
| RBC, 1012/L | − 0.002 | − 0.021 to 0.016 | 0.830 |
| MCHC, g/dL | 0.000 | − 0.001 to 0.001 | 0.926 |
| MCV, fL | 0.089 | − 0.20 to 0.37 | 0.541 |
| WBC, 109/L | − 8.54 | − 59.1 to 42.0 | 0.741 |
| Liver function | |||
| ALP, U/L | − 0.003 | − 0.01–0.006 | 0.496 |
| ALT, U/L* | 0.020 | 0.004–0.035 | 0.014 |
| AST, U/L* | 0.010 | 0.0003–0.021 | 0.044 |
| Total bilirubin, mg/dL* | 0.007 | − 0.009–0.023 | 0.382 |
| Kidney function | |||
| BUN, mg/dL | 0.014 | − 0.07–0.09 | 0.747 |
| GFR, mL/min/1.73 sqm | − 0.095 | − 0.683–0.493 | 0.751 |
| Creatinine, mg/dL* | 0.002 | − 0.005–0.008 | 0.621 |
| Urea, mg/dL* | 0.002 | − 0.008–0.012 | 0.681 |
| Lipid profile | |||
| HDL, mg/dL* | − 0.009 | − 0.015 to − 0.003 | 0.005 |
| LDL, mg/dL* | 0.001 | − 0.007–0.009 | 0.863 |
| Triglycerides, mg/dL* | 0.023 | 0.011–0.036 | < 0.001 |
| Total cholesterol, mg/dL* | 0 | − 0.006–0.006 | 0.874 |
| Electrolyte and minerals | |||
| Calcium, mg/dL | 0.009 | − 0.002–0.020 | 0.098 |
| Chloride, mmol/L | 0.082 | − 0.017–0.181 | 0.110 |
| Sodium, mmol/L* | 0 | − 0.0003–0.001 | 0.242 |
| Potassium, mmol/L | − 0.012 | − 0.024–0.000 | 0.058 |
| Protein | |||
| Albumin, g/dL | 0 | − 0.008–0.009 | 0.918 |
| Total protein, g/dL | 0.003 | − 0.009–0.015 | 0.622 |
| Coagulation | |||
| aPTT, seconds | 0.12 | − 0.006–0.245 | 0.065 |
| PT, seconds* | 0 | − 0.002–0.003 | 0.681 |
| Uric acid, mg/dL | 0.012 | − 0.03–0.054 | 0.587 |
*Indicates skewed data, data were log-transformed before conducting linear regression. Bolded values indicate statistically significant differences (p ≤ 0.05)
Data are presented as regression coefficient and 95% confident interval
ALP, alkaline phosphatase; ALT, alanine transaminase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CIs, confidence intervals; GFR, glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MCHC, mean corpuscular hemoglobin concentration; MVC, mean corpuscular volume; NAD, nicotinamide adenine dinucleotide; PT, patient prothrombin time; RBC, red blood cell; WBC, white blood cell