Table 3.
Association of nicotinamide adenine dinucleotide change per 1 nM increase and blood parameters change (after 60 days)
| B-value | 95% CIs | p-value | |
|---|---|---|---|
| Complete blood count | |||
| Absolute neutrophils, count/cmm | 0.71 | − 10.92 to − 12.34 | 0.904 |
| Eosinophils, %* | 0.010 | − 0.010–0.030 | 0.313 |
| Hemoglobin, g/dL* | 0.027 | 0.01–0.045 | 0.003 |
| Lymphocytes, % | 0.030 | − 0.033 to − 0.003 | 0.353 |
| Monocytes, % | − 0.003 | − 0.017–0.006 | 0.676 |
| Neutrophils, % | − 0.02 | − 0.1–0.4 | 0.480 |
| Platelet count, 109/L | − 160 | − 771–451 | 0.603 |
| RBC, 1012/L* | 0.025 | 0.009–0.042 | 0.003 |
| MCHC, g/dL | 0.016 | 0.008–0.025 | < 0.001 |
| MCV, fL | − 0.057 | − 0.125–0.012 | 0.108 |
| WBC, 109/L | 4.17 | − 13.8–22.1 | 0.650 |
| Liver function | |||
| ALP, U/L | − 0.08 | − 0.24–0.08 | 0.302 |
| ALT, U/L* | − 0.002 | − 0.024–0.02 | 0.861 |
| AST, U/L* | − 0.003 | − 0.025–0.019 | 0.771 |
| Total bilirubin, mg/dL* | − 0.005 | − 0.022–0.011 | 0.520 |
| Kidney function | |||
| BUN, mg/dL | 0.018 | − 0.005–0.040 | 0.124 |
| GFR, mL/min/1.73 sqm | 0.016 | − 0.112–0.144 | 0.807 |
| Creatinine, mg/dL | 0.001 | − 0.001–0.001 | 0.393 |
| Urea, mg/dL | 0.04 | − 0.008–0.09 | 0.103 |
| Lipid profile | |||
| HDL, mg/dL* | 0.001 | − 0.019–0.022 | 0.908 |
| LDL, mg/dL | 0.18 | − 0.11–0.47 | 0.232 |
| Triglycerides, mg/dL | 0.48 | − 0.19–0.15 | 0.164 |
| Total cholesterol, mg/dL | 0.15 | − 0.15–0.44 | 0.324 |
| Electrolyte and minerals | |||
| Calcium, mg/dL | 0.0001 | − 0.004–0.004 | 0.875 |
| Chloride, mmol/L | − 0.20 | − 0.4–0.03 | 0.084 |
| Sodium, mmol/L | − 0.19 | − 0.051–0.013 | 0.258 |
| Potassium, mmol/L | − 0.004 | − 0.009–0.001 | 0.062 |
| Protein | |||
| Albumin, g/dL | 0.001 | − 0.003–0.005 | 0.654 |
| Total protein, g/dL | − 0.001 | − 0.006–0.004 | 0.735 |
| Coagulation | |||
| aPTT, seconds | − 0.004 | − 0.056–0.049 | 0.893 |
| PT, seconds | 0.000 | − 0.012–0.011 | 0.989 |
| Uric acid, mg/dL* | 0.020 | 0.003–0.038 | 0.026 |
*Indicates skewed data, data were log-transformed before conducting linear regression. Bolded values indicate statistically significant differences (p ≤ 0.05)
Data are presented as regression coefficient and 95% confident interval
abs. neutr., absolute neutrophils; ALP, alkaline phosphatase; ALT, alanine transaminase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CIs, confidence intervals; GFR, glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MCHC, mean corpuscular hemoglobin concentration; MVC, mean corpuscular volume; NAD, nicotinamide adenine dinucleotide; PT, patient prothrombin time; RBC, red blood cell; WBC, white blood cell