BBB	Blood–brain barrier
BTB	Blood–tumor barrier
CAR-T	Chimeric antigen receptor T-cell
CBTRUS	Central Brain Tumor Registry of the United States
CED	Convection-enhanced delivery
cGAS	Cyclic GMP–AMP synthase
CMC	Chemistry, manufacturing, and controls
CNS	Central nervous system
CRISPR	Clustered regularly interspaced short palindromic repeats
cRGD	Cyclic arginine–glycine–aspartic acid
ECM	Extracellular matrix
EORTC	European Organisation for Research and Treatment of Cancer
EPR	Enhanced permeability and retention
FcRn	Neonatal Fc receptor
GBM	Glioblastoma
GEMM	Genetically engineered mouse model
GMP	Good manufacturing practice
gp60	Glycoprotein 60
HSA	Human serum albumin
HMGB1	High-mobility group box 1
IDH	Isocitrate dehydrogenase
IHC	Immunohistochemistry
IL	Interleukin
IRE	Inositol-requiring enzyme
KU70	Ku70 DNA repair protein
LIPU/MB	Low-intensity pulsed ultrasound with microbubbles
LMWP	Low-molecular-weight protamine
LRP1	Low-density lipoprotein receptor-related protein 1
MDSC	Myeloid-derived suppressor cell
MPACT	Metastatic Pancreatic Adenocarcinoma Clinical Trial
MR	Magnetic resonance
mTOR	Mechanistic target of rapamycin
nab	Nanoparticle albumin-bound
NCIC	National Cancer Institute of Canada
NSCLC	Non-small cell lung cancer
optoBBTB	Optical blood–brain–tumor barrier
OS	Overall survival
PDOX	Patient-derived orthotopic xenograft
PDX	Patient-derived xenograft
PEG	Polyethylene glycol
PFS	Progression-free survival
PK	Pharmacokinetic
PRISMA	Preferred Reporting Items for Systematic Reviews and Meta-Analyses
RANO	Response Assessment in Neuro-Oncology
RGD	Arginine–glycine–aspartic acid
RNA	Ribonucleic acid
ROS	Reactive oxygen species
siRNA	Small interfering RNA
SPARC	Secreted protein acidic and rich in cysteine
SSR3	Signal sequence receptor subunit 3
STAT3	Signal transducer and activator of transcription 3
STING	Stimulator of interferon genes
TAM	Tumor-associated macrophage
TEER	Transendothelial electrical resistance
TLR4	Toll-like receptor 4
TME	Tumor microenvironment
TRAIL	TNF-related apoptosis-inducing ligand
Treg	Regulatory T cell