ADCC	antibody-dependent cellular cytotoxicity
AlloCAR70-NKT	CD70-directed allogeneic CAR-NKT cells
apCAFs	antigen-presenting cancer-associated fibroblasts
CAFs	cancer-associated fibroblasts
CAIX	carbonic anhydrase IX
CAR	chimeric antigen receptor
CAR-NKT	CAR-engineered natural killer T cells
circRNAs	circular RNAs
COX-2	cyclooxygenase-2
CSR	chimeric interleukin-2 signalling receptor
DCs	dendritic cells
dnTGFβRII	dominant-negative transforming growth factor beta receptor II
dSTORM	direct stochastic optical reconstruction microscopy
EGFR	epidermal growth factor receptor
EMT	epithelial–mesenchymal transition
GVHD	graft-versus-host disease
HSPCs	haematopoietic stem and progenitor cells
iCAFs	inflammatory cancer-associated fibroblasts
ICB	immune checkpoint blockade
IDO	indoleamine 2,3-dioxygenase
IL-2	interleukin-2
iNKT	invariant natural killer T cells
iPSCs	induced pluripotent stem cells
IR	immune-restoring
LDH	lactate dehydrogenase
LNPs	lipid nanoparticles
LOX	lysyl oxidase
MDSCs	myeloid-derived suppressor cells
MMPs	matrix metalloproteinases
myCAFs	myofibroblastic cancer-associated fibroblasts
NK	natural killer
NKR	natural killer receptor
NKRs	natural killer receptors
NKT	natural killer T cells
OTOT	on-target off-tumour
PD-L1	programmed death ligand 1
PDOTS	patient-derived organotypic tumour spheroid
PDX	patient-derived xenograft
PRCC	papillary renal cell carcinoma
Tfh	T follicular helper cell
TKIs	tyrosine kinase inhibitors
TLS	tertiary lymphoid structure
TME	tumour microenvironment
TRAC	T cell receptor alpha constant
Treg	regulatory T cell
VEGF	vascular endothelial growth factor
VHL	von Hippel–Lindau
α-GC	α-galactosylceramide