Figure 1.

Global remodeling of collagen matrices. HD matrices (□), LD matrices (▪), or matrices without cells (×) were incubated for the times shown in basal medium (BSA) or medium containing LPA or PDGF. At the end of the incubations, contraction was determined by measuring reduction in cell height. In the presence of LPA or PDGF, matrix contraction was ∼50% by 1 h and 80–90% by 6 h (starting height ∼1.8–1.9 mm). In basal medium, the rate of contraction was slower with little contraction observed after 1 h and only 60–70% by 6 h. Studies were carried out in triplicate. SDs were smaller than the size of the points.