Figure 2.

Local remodeling of collagen matrices. Images of cells from LD matrices at 1 h (green) and 4 h (red) in basal medium (BSA) or medium containing LPA or PDGF as indicated. Overlay shows displacement of beads during the incubations. Little bead displacement occurred in LD matrices in basal medium, although cell extensions were prominent and undergoing protrusion and withdrawal. Centripetal displacement of beads occurred in matrices in medium containing LPA or PDGF. Data shown are from representative films; two to four films were made for each condition. Bar, 20 μM.