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. 2026 Jul 7;18(13):2181. doi: 10.3390/cancers18132181
AL  Anastomotic leakage
CRC Colorectal cancer
RCTs Randomized controlled trials
MMP-9 Matrix metalloproteinase-9 
CoReAL The International Consensus on Reporting Anastomotic Leaks After Colorectal Cancer Surgery
ISREC International Study Group of Rectal Cancer 
CRP C-reactive protein 
PCT Procalcitonin 
SCFAs Short-chain fatty acids 
GOS Galacto-oligosaccharides 
HDAC Histone deacetylase 
PLG Human plasminogen 
FMT Fecal microbiota transplantation 
MBP Mechanical bowel preparation
OAB Selective Oral Antibiotics
NOX1 NADPH oxidase 1 
PEG Polyethylene glycol 
ESCP European Society of Coloproctology 
WGO The World Gastroenterology Organisation 
AEProbio Alliance for Education on Probiotics 
RR Relative risk 
CI Confidence interval
ARS Anterior resection syndrome 
ERAS Enhanced Recovery After Surgery 
NLR Neutrophil-to-lymphocyte ratio