Table 4. Semiquantitative histopathological grading of medial degeneration features.
|
Histopathological feature (SCVP criteria) |
Absent |
Mild |
Moderate |
Severe |
MEMA type |
|
MEMA |
27 |
18 |
19 |
14 |
Intralamellar: 38 |
|
Translamellar: 13 | |||||
|
Elastic fiber fragmentation |
31 |
23 |
16 |
8 |
- |
|
Elastic fiber thinning |
34 |
24 |
15 |
5 |
- |
|
SMC loss |
35 |
20 |
14 |
9 |
- |
|
Laminar medial collapse |
50 |
15 |
8 |
5 |
- |
|
Medial fibrosis |
58 |
12 |
6 |
2 |
- |
|
Cystic spaces |
62 |
9 |
5 |
2 |
- |
|
Inflammatory infiltration |
63 |
8 |
5 |
2 |
- |
SCVP: Society for Cardiovascular Pathology; SMC: Smooth muscle cell; MEMA: Mucoid extracellular matrix accumulation.