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In vitro inhibition assay of kinases of tau by inhibitors HD and FL. (a) MARK2. (b) GSK3β. Note that GSK-3β is inhibited by HD (IC50 = 0.13 μM) and FL (IC50 = 0.55 μM), but MARK2 is inhibited mainly by HD (IC50 = 0.67 μM), whereas FL is only a weak inhibitor (IC50 = 38 μM).
