Table 2.
Pharmacokinetic measures of meropenem according to sampling site
| Antimicrobial | Infusion time | Blood samples type | Cmax (mg/L) | Tmax (h) |
AUC0−24 (mg · h/L) | Kel (h− 1) |
T1/2 (h) |
CL (L/h) |
Vd (L) |
|---|---|---|---|---|---|---|---|---|---|
| Meropenem | 4 h | Pre-M [n = 24] | 49.9 ± 33.1 | 3.44 ± 1.10 | 533 ± 270 | 0.336 ± 0.0746 | 2.15 ± 0.520 | 11.1 ± 3.89 | 35.0 ± 6.16 |
| Post-M [n = 24] | 46.0 ± 26.9 | 3.46 ± 1.11 | 530 ± 268 | 0.329 ± 0.123 | 2.45 ± 1.25 | 11.2 ± 3.97 | 38.5 ± 7.25 | ||
|
AL [n = 29] |
43.6 ± 29.0 | 3.48 ± 1.11 | 434 ± 174 | 0.302 ± 0.106 | 2.57 ± 1.06 | 12.7 ± 3.39 | 43.8 ± 8.08 | ||
| p-value | 0.946 | 0.925 | 0.809 | 0.884 | 0.828 | 0.795 | 0.270 |
All PK measures are expressed as mean ± SD. Values in brackets [n = x] indicate the number of concentration-time points used for the non-compartmental analysis
AL: arterial line. AUC0–24: area under the plasma concentration–time curve from 0 to 24 h; CL: clearance; Cmax: maximum plasma concentration; Kel: elimination rate constant. Post-M: post-membrane concentrations; Pre-M: pre-membrane concentrations; T1/2: half-life; Tmax: time to maximum concentration; Vd: volume of distribution