Table 4.
Pharmacokinetic measures of linezolid according to sampling site
| Infusion time | Blood samples type | Cmax (mg/L) | Tmax (h) |
AUC0−24 (mg · h/L) | Kel (h− 1) |
T1/2 (h) |
CL (L/h) |
Vd (L) |
|---|---|---|---|---|---|---|---|---|
| 1 h |
Pre-M [n = 16] |
14.9 ± 4.81 | 1.24 ± 0.150 | 152 ± 62.3 | 0.170 ± 0.0713 | 4.79 ± 2.53 | 9.05 ± 4.21 | 58.6 ± 28.0 |
|
Post-M [n = 16] |
14.5 ± 5.33 | 1.27 ± 0.150 | 154 ± 64.2 | 0.169 ± 0.0622 | 4.49 ± 1.59 | 8.92 ± 4.14 | 53.5 ± 16.6 | |
|
AL [n = 19] |
13.6 ± 2.07 | 1.29 ± 0.167 | 130 ± 42.0 | 0.185 ± 0.0735 | 4.17 ± 1.68 | 10.1 ± 3.93 | 56.3 ± 14.8 | |
| p-value | 0.932 | 0.926 | 0.850 | 0.946 | 0.930 | 0.927 | 0.956 |
All PK measures are expressed as mean ± SD. Values in brackets [n = x] indicate the number of concentration-time points used for the non-compartmental analysis
AL: arterial line. AUC0–24: area under the plasma concentration–time curve from 0 to 24 h; CL: clearance; Cmax: maximum plasma concentration; Kel: elimination rate constant. Post-M: post-membrane concentrations; Pre-M: pre-membrane concentrations; T1/2: half-life; Tmax: time to maximum concentration; Vd: volume of distribution