sFRP4	secreted frizzled-related protein 4
sFRPs	secreted frizzled-related proteins sFRPs
TME	tumor microenvironment
CRD	cysteine-rich domain
FZD	Frizzled
GSK-3β	glycogen synthase kinase-3β
JNK	c-Jun N-terminal kinase
NLD	netrin-like domain
TFs	transcription factors
DNMT	DNA methyltransferase
CSCs	cancer stem cells
EAC	esophageal adenocarcinoma
PDAC	pancreatic ductal adenocarcinoma
3′-UTR	3′ untranslated region
ESCC	esophageal squamous cell carcinoma
SCC	squamous cell carcinoma
5-aza-dC	5-aza-2′-deoxycytidine
EMT	epithelial–mesenchymal transition
rsFRP4	recombinant sFRP4 protein
PanIN	pancreatic intraepithelial neoplasia
ASCs	adipose stromal cell
PSCs	pancreatic stellate cells
HCC	hepatocellular carcinoma
OSCC	oral squamous cell carcinoma
TCF/LEF	T-cell factor/lymphoid enhancer factor
MM	malignant mesothelioma
GBM	glioblastoma
APL	acute promyelocytic leukemia
AML	acute myeloid leukemia
ALL	acute lymphoblastic leukemia
CLL	chronic lymphocytic leukemia
AFP	alpha-fetoprotein
NACT	neoadjuvant chemotherapy
rhsFRP4	recombinant human sFRP4 protein
TIO	tumor-induced osteomalacia
FGF23	fibroblast growth factor 23
CS–DS	chitosan–glucan sulfate
LRP5/6	low-density lipoprotein receptor-related protein 5/6
PLC	phospholipase C
IP3	inositol 1,4,5-trisphosphate
PKC	protein kinase C
NFAT	nuclear factor of activated T-cells
PD-L1	Programmed Death-Ligand 1
PD-1	Programmed Cell Death Protein 1
DKK3	Dickkopf WNT signaling pathway inhibitor 3
METTL7B	Methyltransferase like 7B
MNS1	Meiosis Specific Nuclear Structural 1
MMP	matrix metalloproteinase
BE	Barrett’s Esophagus
CC	Cervical Cancer
BC	Bladder Cancer
EC	Endometrial Cancer
OC	Ovarian Cancer
GC	Gastric Cancer
CRC	Colorectal Cancer
PCa	Prostate Cancer
HGSOC	High-Grade Serous Ovarian Cancer