ASO	Antisense oligonucleotide
CAF	Cancer-associated fibroblast
CNS	Central nervous system
CRC	Colorectal cancer
ctDNA	Circulating tumor DNA
ECM	Extracellular matrix
EGFR	Epidermal growth factor receptor
EMT	Epithelial-to-mesenchymal transition
FDA	U.S. Food and Drug Administration
FTI	Farnesyltransferase inhibitor
GAP	GTPase-activating protein
GDP	Guanosine diphosphate
GEF	Guanine nucleotide exchange factor
GTP	Guanosine triphosphate
HR	Hazard ratio
MAPK	Mitogen-activated protein kinase
MEK	Mitogen-activated protein kinase kinase
mCRC	Metastatic colorectal cancer
MRD	Minimal residual disease
NSCLC	Non-small-cell lung cancer
ORR	Objective response rate
OS	Overall survival
PDAC	Pancreatic ductal adenocarcinoma
PFS	Progression-free survival
PI3K	Phosphoinositide 3-kinase
PROTAC	Proteolysis-targeting chimera
RAF	Rapidly accelerated fibrosarcoma kinase
RAS(ON)	Active-state RAS
RTK	Receptor tyrosine kinase
SHP2	Src homology region 2-containing protein tyrosine phosphatase 2
S-IIP	Switch-II pocket
siRNA	Small interfering RNA
SOS1	Son of sevenless homolog 1
TME	Tumor microenvironment