Table 1.
Top 50 metabolites potential biomarkers from I. hoferi-infected and control White Stumpnose (Rhabdosargus globiceps) DBS samples with their respective PLS-DA VIP values, fold changes, chemical classification, and KEGG numbers.
| Upregulated metabolites | VIP | Fold change | Chemical class | KEGG number |
|---|---|---|---|---|
| Cyclohexane | 10.94 | Up | XEN | KEGG Compound C11249 |
| Propanoic acid | 7.47 | Up | Carboxylic acid | KEGG Compound C00163 |
| 5-Decyne | 7.03 | Up | XEN | N/A |
| 1,3-Benzenedicarboxylic acid | 5.62 | Up | FA | N/A |
| Analyte 482 | 5.36 | Up | N/A | N/A |
| Pentos-3-ulose | 4.48 | Up | Carb | N/A |
| Dotriacontane | 3.97 | Up | XEN | N/A |
| Benzoic acid | 3.90 | Up | XEN | KEGG Compound C00180 |
| Myo-Inositol | 3.19 | Up | Carb | KEGG Compound C00137 |
| Palmitoleic-Acid | 3.16 | Up | FA | N/A |
| Analyte 621 | 2.884 | Up | N/A | N/A |
| Oxalic acid | 2.851 | Up | Carb | KEGG Compound C00209 |
| Ribitol | 2.691 | Up | Carb | KEGG Compound C00474 |
| Nonadecanol | 2.677 | Up | FA | N/A |
| D-Pinitol | 2.329 | Up | FA | KEGG Compound C03844 |
| Heptadecanoic acid | 2.173 | Up | FA | N/A |
| 9-Tetradecenoic-Acid | 2.109 | Up | FA | N/A |
| 2-methyloctacosane | 1.796 | Up | XEN | N/A |
| Cyclooctasiloxane | 1.786 | Up | XEN | N/A |
| Downregulated Metabolites | VIP | Fold Change | Chemical Class | KEGG Number |
| Phthalic acid | 10.95 | Down | XEN | KEGG Compound C01606 |
| 1,2-Benzenedicarboxylic acid | 10.54 | Down | XEN | KEGG Compound C01606 |
| Analyte 279 | 8.86 | Down | N/A | N/A |
| 1,2-Benzenedicarboxylic-Acid | 7.19 | Down | Aromatic dicarboxylic acid | N/A |
| Arabinofuranose | 7.13 | Down | Carb | KEGG Compound C06115 |
| Pentadecanoic acid | 6.03 | Down | FA | KEGG Compound C16537 |
| Hexanedioic acid | 5.76 | Down | Organic compound | KEGG Compound C06104 |
| Tetraoxa | 4.33 | Down | XEN | N/A |
| Adipic-Acid | 4.10 | Down | FA | N/A |
| d-Mannose | 3.46 | Down | Carb | KEGG Compound C00159 |
| Analyte 565 | 3.27 | Down | N/A | N/A |
| 1,1’-Biphenyl, 2,2’,5,5’-tetramethyl | 3.06 | Down | XEN | N/A |
| Siloxane | 2.722 | Down | Xeno | N/A |
| Oleic acid | 2.602 | Down | FA | KEGG Compound C00712 |
| Butanedioic acid | 2.489 | Down | FA | KEGG Compound C00042 |
| Analyte 875 | 2.473 | Down | N/A | N/A |
| Isopropyl myristate | 2.338 | Down | XEN | N/A |
| Methane, di-p-tolyl | 2.181 | Down | XEN | N/A |
| Analyte 315 | 2.173 | Down | N/A | N/A |
| Analyte 823 | 1.987 | Down | N/A | N/A |
| Benzene | 1.852 | Down | XEN | KEGG Compound C01407 |
| Pentanedioic acid | 1.784 | Down | XEN | KEGG Compound C00489 |
| Analyte 940 | 1.775 | Down | XEN | N/A |