TABLE 1.
Analysis of embryos from Rev3−/− crossesa
| No. of days of gestation | No. of fetuses with genotype:
|
No. of observed/ no. of expected Rev3−/− embryos | ||
|---|---|---|---|---|
| Rev3+/+ | Rev3+/− | Rev3−/− | ||
| 9.5 | 23 | 29 | 10 (6) | 0.64 |
| 10.5 | 36 | 67 | 22 (2) | 0.70 |
| 11.5 | 11 | 12 | 3 (3) | 0.46 |
| 12.5 | 5 | 3 | 0 (3) | 0 |
| 13.5 | 4 | 4 | 0 (0) | 0 |
| Weaned | 73 | 155 | 0 | 0 |
a
Pregnant females were sacrificed, and embryos were isolated. Crosses shown here were from backcrosses to the C57BL/6 background (generation F1 to F3). The given number of Rev3−/− embryos does not include the resorbing embryos, the number of which is shown in parentheses. All Rev3−/− embryos displayed growth retardation of between 1 and 3 days (Fig. 2). The ratio between the number of observed and the number of expected Rev3−/− embryos refers to the live embryos only.