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Establishment of Rev3−/− blastocyst cultures from mice with a mixed 129/OLA and C57BL/6 background and sensitivity of the inner cell masses to paraoxon and NA-AAFa
| Treatment | No. surviving/total no. of blastocysts
|
||
|---|---|---|---|
| Rev3+/+ | Rev3+/− | Rev3−/− | |
| None | 12/13 | 21/22 | 6/8 |
| Paraoxon | 5/5 | 9/10 | 4/4 |
| Paraoxon + NA-AAF | 8/8 | 17/17 | 0/9 |
Blastocysts (3.5 dpc) were isolated and treated after attachment to the well (at 5.5 to 6.5 dpc). Survival was monitored at 48 h after treatment.
