TABLE 3.
Enhanced frequencies of all types of chromosomal aberrations derived from Rev3−/− embryos, as determined by COBRA analysisa
| Genotype | Embryo no. | No. of normal metaphases | No. of chromosome and chromatid breaks | No. of chromatid exchanges | No. of translocations | Total no. of aberrations |
|---|---|---|---|---|---|---|
| Wild type | 1 | 60 | 0 | 0 | 0 | 0 |
| Wild type | 2 | 39 | 1 | 0 | 0 | 1 |
| Rev3+/− | 3 | 50 | 0 | 0 | 0 | 0 |
| Rev3−/− | 4 | 43 | 2 | 3 | 2 | 7 |
| Rev3−/− | 5 | 32 | 1 | 1 | 0 | 2 |
| Rev3−/− | 6 | 41 | 3 | 3 | 1 | 7 |
a
Note that, as a consequence of the limited spatial resolution of the painted chromosomes, the actual number of chromosome and chromatid breaks probably is higher than that detected in this experiment.