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. 2002 Apr;22(7):2267–2282. doi: 10.1128/MCB.22.7.2267-2282.2002

FIG. 6.

FIG. 6.

Altered histone mRNA expression in dSLBP mutant embryos. Each panel shows a whole mount in situ hybridization of a stage 14 embryo (anterior at left, dorsal at top) using a coding region histone probe. (A) Wild-type H2a expression is restricted to replicating cells, including those in the proliferating CNS (arrowhead) and endoreduplicating midgut (right arrow). The cells of the anterior midgut (left arrow) have exited S phase and do not express histone H2a mRNA. (B) Wild-type histone H2b expression is identical to H2a. (C) In dSLBP15/dSLBP15 mutant embryos, histone H2a mRNA persists in cells that have finished replicating (e.g. the anterior midgut; arrow), generating a diagnostic aberrant pattern. (D) H2b mRNA also accumulates in nonreplicating dSLBP15/dSLBP15 mutants cells (arrow) in a manner similar to H2a mRNA.

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