TABLE 1.
BWs and HWs of Akt transgenic and NTg micea
Age (wks) and mice | No. of mice | BW (g) | HW (mg) | Lung wt (mg) | Liver wt (mg) | HW/BW ratio | Lung wt/BW ratio | Liver wt/BW ratio |
---|---|---|---|---|---|---|---|---|
2 | ||||||||
NTg | 7 | 9.0 ± 0.3 | 53.7 ± 2.3 | 100.5 ± 5.2 | 371 ± 25 | 5.98 ± 0.11 | 11.19 ± 0.46 | 41.1 ± 2.1 |
caAkt | 6 | 7.7 ± 0.2 | 100.3 ± 4.1b | 132.2 ± 3.5b | 353 ± 11 | 13.02 ± 0.42b | 17.23 ± 0.73b | 45.6 ± 2.1 |
kdAkt | 6 | 8.5 ± 0.4 | 8.5 ± 3.3 | 97.9 ± 7.0 | 366 ± 2.0 | 6.05 ± 0.22 | 10.99 ± 0.26 | 41.3 ± 0.9 |
14 | ||||||||
NTg | 15 | 22.9 ± 0.5 | 104.3 ± 2.1 | 134.3 ± 5.2 | 1,075 ± 33 | 4.57 ± 0.08 | 5.88 ± 0.16 | 47.0 ± 1.2 |
caAkt | 13 | 21.6 ± 0.4 | 213.1 ± 4.6b | 185.8 ± 5.0b | 1,050 ± 29 | 9.88 ± 0.22b | 8.62 ± 0.25b | 48.6 ± 0.9 |
kdAkt | 4 | 23.1 ± 0.9 | 107.9 ± 5.6 | 125.3 ± 3.1 | 1,049 ± 67 | 4.67 ± 0.09 | 5.46 ± 0.27 | 46.0 ± 4.7 |
The values shown are means ± SE. In the 2-week-old groups, both male and female mice were used for analysis. In the 14-week-old groups, only female mice were used.
P < 0.05 versus NTg mice.