TABLE 2.
Peripheral blood analysisa
| Hematological parameter | Value for mice with genotype:
|
|||
|---|---|---|---|---|
| fps+/+ | fps+/− | fps−/− | fps−/−:Tg | |
| White blood cells (103/μl) | 8.69 ± 3.42 (89) | 7.91 ± 2.39 (94) | 8.62 ± 2.67 (53) | 9.47 ± 2.98 (29) |
| Neutrophils (%) | 23 ± 14.6 (89) | 21 ± 14.5 (94) | 19.5 ± 13.6 (53) | 25.5 ± 14.6 (29) |
| Lymphocytes (%) | 76.2 ± 18.2 (89) | 70.4 ± 17 (94) | 72.6 ± 17.2 (53) | 65.6 ± 18.3 (29) |
| Monocytes (%) | 5.82 ± 5.55 (89) | 5.14 ± 4.75 (94) | 4.77 ± 4.99 (53) | 5.22 ± 4.73 (29) |
| Eosinophils (%) | 1.68 ± 1.57 (89) | 1.6 ± 1.69 (94) | 1.4 ± 1.39 (53) | 1.82 ± 1.95 (29) |
| Basophils (%) | 2.3 ± 2.47 (89) | 1.91 ± 2.18 (94) | 1.64 ± 1.36+ (53) | 1.87 ± 1.17 (29) |
| Erythrocytes (106/μl) | 9.20 ± 1.15 (89) | 9.20 ± 0.97 (94) | 9.72 ± 0.55* (53) | 8.87 ± 0.87 (29) |
| Hemoglobin (g/liter) | 147.2 ± 12.98 (89) | 147.6 ± 10.99 (94) | 154 ± 7.28# (53) | 145.9 ± 9.58 (29) |
| Hematocrit (liter/liter) | 0.460 ± 0.038 (89) | 0.459 ± 0.035 (94) | 0.480 ± 0.022# (53) | 0.456 ± 0.031 (29) |
| Mean corpuscular vol (fl) | 50.30 ± 3.51 (89) | 50.25 ± 2.91 (94) | 49.47 ± 2.04 (53) | 51.61 ± 2.89 (29) |
| Mean corpuscular hemoglobin (pg) | 16.1 ± 1.01 (89) | 16.16 ± 0.94 (94) | 15.85 ± 0.65 (53) | 16.52 ± 0.89 (29) |
| Mean corpuscular hemoglobin concn (g/liter) | 319.82 ± 6.49 (89) | 321.35 ± 5.30 (93) | 320.57 ± 5.44 (53) | 320.13 ± 4.05 (29) |
| Platelets (103/μl) | 966.6 ± 304.7 (89) | 1,043 ± 282.1 (94) | 926.1 ± 267 (53) | 1013 ± 320 (29) |
| Mean platelet vol (fl) | 6.83 ± 0.64 (89) | 6.91 ± 0.58 (94) | 6.74 ± 0.56 (53) | 7.14 ± 1.2 (29) |
| Body wt (g) | 31.63 ± 6.82 (75) | 28.17 ± 6.24 (71) | 29.56 ± 7.72 (38) | 30.29 ± 4.08 (27) |
| Spleen wt (mg) | 139.25 ± 65.91 (75) | 117.62 ± 34.88 (71) | 112.51 ± 32.74# (38) | 94.86 ± 38.24 (27) |
| % Spleen wt | 0.46 ± 0.22 (75) | 0.44 ± 0.16 (71) | 0.41 ± 0.16 (38) | 0.32 ± 0.12 (27) |
| Age of mice (days) | 65.12 ± 19.13 (89) | 63.43 ± 24.15 (94) | 67.66 ± 19.26 (53) | 81.55 ± 17.42 (29) |
a
Values represent the mean ± standard deviation (sample size) for each parameter. Statistically significant differences between wild-type and homozygous animals are indicated in boldface. P values were calculated using the Student t test: +, P < 0.04; *, P ≤ 0.0022; and #, P ≤ 0.0005.