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. 2026 May 21;24:914. doi: 10.1186/s12967-026-07859-y

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — miR-3614-5p is decreased in CRC plasma exosomes, tissues, and cell lines. (A) The flowchart of identifying differentially expressed miRNAs in plasma exosomes between the healthy control and CRC patients. (B and C) The volcano plots a heatmap showing the differentially expressed exosomal miRNAs between CRC patients and healthy controls. (D) The differentially expressed miRNAs in CRC tissues from TCGA databases. (E) Venn diagram showed the overlapping miRNAs among miRNA-seq of exosomes, differentially expressed miRNAs in CRC tissues from the TCGA database, and prognostic factor from the TCGA database. (F) RT-qPCR was performed to detect the expression of miR-3614-5p in the plasm or plasm exosomes of CRC patients and healthy controls. (G and H) RT-qPCR was performed to detect the expression of miR-3614-5p in CRC tissues or CRC cell lines and adjacent tissues or normal cell line. (I) The TCGA database shows the expression profile of miR-3614-5p in colorectal adenocarcinoma (COAD). (J) The Kaplan-Meier survival curve showed a correlation between miR-3614-5p expression and overall survival in CRC patients