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. 2026 May 21;24:914. doi: 10.1186/s12967-026-07859-y

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — hMSC-derived Exo-miR-3614-5p and its inhibitory effect in CRC. (A) Schematic diagram of hMSC derived exosomes for CRC treatment. (B-D) Exosomes were identified by Transmission Electron Microscopy (TEM), Scale bars = 100 μm, Nanosight tracking analysis (NTA), and Western blot. (E and F) qRT-PCR detects the expression of miR-3614-5p in exosomes derived from hMSCs transfected with miR-3614-5p mimics or mimic NC. (G-I) CCK8, wound healing, and transwell assays were used to evaluate the effects of hMSC derived exosomal miR-3614-5p on CRC cell proliferation, migration, and invasion. Scale bars = 500 μm (H) and 100 μm (I)