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. 2026 May 21;24:914. doi: 10.1186/s12967-026-07859-y

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 7 — Exo-miR-3614-5p inhibits tumor growth in vivo. (A) Transplanted tumors models were established by subcutaneously inoculating HCT116 cells into tumor-bearing nude mice, which were then divided into two groups upon tumor formation. The groups included: (1) Exo-miR-NC control; (2) Exo-miR-3614-5p, n = 6. (B-C) Transplanted tumor volume and tumors in nude mice treated with tail vein injection of Exo-miR-3614-5p, n = 6. (D-E) qRT-PCR detection of the miR-3614-5p and IL7Rα in tumor tissues. (F) Western blot detection of the IL7Rα, p-JAK2, JAK2, p-STAT3, STAT3, and Ki67 protein expression in tumor tissues. (G) Immunohistochemical staining of the IL7Rα, p-JAK2, p-STAT3, and Ki67 protein expression in tumor tissues. Scale bars = 100 μm (unenlarged picture) and 20 μm (enlarge Image)