TABLE 1.
Echocardiography of S100A1 null and wild-type mice (n = 10 per group)a
| Group | Heart rate (beats/min) | LVEDd (mm) | LVEDs (mm) | FS (%) |
|---|---|---|---|---|
| Wild type | ||||
| KXA | 417 ± 17 | 3.5 ± 0.2 | 2.2 ± 0.2 | 38 ± 3 |
| KXA + isoproterenol | 621 ± 12 | 2.8 ± 0.1 | 0.9 ± 0.1 | 69 ± 2 |
| Conscious | 648 ± 30 | 2.8 ± 0.1 | 1.2 ± 0.1 | 60 ± 3 |
| S100A1 null | ||||
| KXA | 384 ± 15 | 3.6 ± 0.2 | 2.4 ± 0.2 | 32 ± 2 |
| KXA + isoproterenol | 594 ± 13 | 2.8 ± 0.1 | 1.1 ± 0.1 | 62 ± 2b |
| Conscious | 601 ± 28 | 3.1 ± 0.1 | 1.5 ± 0.1 | 52 ± 4 |
a
LVEDd, left-ventricular end diastolic diameter; LVEDs, left-ventricular end systolic diameter; FS, fractional shortening {FS = [(LVEDd − LVEDs)/LVEDd] × 100}; KXA, ketamine-xylazine-atropine anesthetized. Data are means ± standard errors.
b
P < 0.05 versus the wild-type value.