FIG. 5.

Inducer-specific occupancy of the activator binding sites in the TNF-α promoter region. A model of the cis-acting TNF-α promoter elements and transcription factors involved in the inducer-specific regulation of TNF-α by ionophore and virus in T cells is summarized schematically. Activator binding sites that are critical for activation of the promoter are shown in colored boxes. The transcription factors that are recruited to the TNF-α promoter (NFAT, Sp1, Ets, and ATF-2/c-Jun) following the indicated stimuli are shown in different shapes and colors.