Skip to main content
. 2002 Apr;22(8):2663–2672. doi: 10.1128/MCB.22.8.2663-2672.2002

FIG. 1.

FIG. 1.

E2F3 is essential for full embryonic viability, promotes growth in a dose-dependent manner, and is critical for normal cardiac function. (A) Progeny arising from E2f3+/− intercrosses at various stages of embryonic development. Numbers in parentheses indicate numbers of nonviable embryos found at each developmental stage. (B) Representative weight curve of female littermate animals. Similar data was obtained for other litters and for males; however, the number of animals examined was insufficient to allow statistical analysis. (C) Kaplan-Meier plots of wild-type (n = 30), E2f3+/− (n = 27), and E2f3−/− (n = 25) littermates with the mixed (C57/BL6 × 129/Sv) genetic background and wild-type (n = 20) and E2f3+/− (n = 19) littermates with the pure 129/Sv background. (D) Hematoxylin- and eosin-stained sections of the lungs (×40 magnification) of an E2f3−/− animal that died from congestive heart failure, displaying macrophages in the alveolar spaces. (E and F) Sections of hearts (×1 and ×5 magnification, respectively) from E2f3−/− mice, depicting atrial thrombi stained with Gomori's one-step trichrome stain. LA, left atrium. LV, left ventricle.