Skip to main content
. 2002 Apr;22(8):2663–2672. doi: 10.1128/MCB.22.8.2663-2672.2002

FIG. 3.

FIG. 3.

Aging phenotypes of E2f1 E3f3 compound mutant animals. (A) Relative life spans of mixed (C57BL/6 X129/Sv) E2f1+/− (n = 10), E2f1−/− (n = 18), E2f1+/− E2f3+/− (n = 41), and E2f1−/− E2f3+/− (n = 27) mice. (B) Hematoxylin- and eosin-stained sections of kidneys from a control wild-type animal and from an E2f1−/− E2f3+/− animal that died at 6 months of age with severe glomerulonephritis. (C) Signs of congestive heart failure in an E2f1+/− E2f3+/− animal that died at 8 months of age. The histological section of the left atrium of the heart (×5 magnification) was stained with Gomori's one step trichrome stain, and the section of the lung (×40 magnification) was stained with hematoxylin and eosin.