TABLE 2.
Phenotypes and time of death of E2f1 E2f3 compound mutant animals
| Phenotype | Age at death (mo)
|
||
|---|---|---|---|
| E2f1+/− or E2f1−/− (n = 24) | E2f1+/−E2f3+/− (n = 37) | E2f1−/−E2f3+/− (n = 16) | |
| Tumor | |||
| Histiocytic sarcoma | 16, 17, 17.5, 19, 19.5, 22.5, 23, 23.5 | 12.5, 18, 18, 20.5, 21.5, 21.5, 27.5, 32 | 13, 18, 18.5, 21, 26.5 |
| Hemangiosarcoma | 19, 19.5, 22.5 | 11.5, 14.5, 18, 20.5, 21.5, 23, 24.5, 26, 29 | 13, 17.5 |
| Hepatocarcinoma | 18 | 17, 23.5, 27 | 18.5, 31.5 |
| Adenocarcinoma | 15.5, 20, 22, 22.5 | 20.5, 24, 29 | 31.5 |
| Lymphoma-leukemia | 21, 22, 22, 22.5 | 15, 17.5, 18, 18, 19, 21, 27 | |
| Pheochromocytoma | 16.5 | 22.5 | |
| Other | |||
| Glomerulonephritis | 14.5, 21 | 8, 14, 15, 16.5, 19 | 6, 10, 16, 18, 19 |
| Polyarteritis nodosa | 14.5, 21, 21 | 10, 12.5, 19 | |
| Congestive heart failure | 8, 14, 17, 17 | 20, 22.5, 24.5 | |