Table 2.
Logistic regression comparing association between risk factors and age at CRC diagnosis (late-onset, LOCRC vs. early-onset, EOCRC)
| Exposures | LOCRC/EOCRC (%) | Adjusted OR# (95% CI) | p-value |
|---|---|---|---|
| Lifestyle | |||
| Body mass index | |||
| Underweight | 7.1/6.6 | 0.75 (0.49, 1.14) | 0.6542 |
| Overweight | 30.8/27.8 | 0.89 (0.69, 1.15) | 0.2154 |
| Obese | 31.7/41.2 | 0.61 (0.48, 0.77) | 0.0009* |
| Normal weight | 30.3/24.5 | Reference | |
| Smoking status | |||
| Current | 15.8/17.7 | 1.10 (0.84, 1.43) | 0.0849 |
| Former | 35.5/22.3 | 1.89 (1.50, 2.39) | <.0001* |
| Never | 48.7/60.0 | Reference | |
| Clinical | |||
| Hypertension | |||
| Yes | 11.9/5.0 | 2.46 (1.65, 3.66) | <.0001* |
| No | 88.1/95.0 | Reference | |
| Type 2 diabetes | |||
| Yes | 19.2/10.4 | 1.92 (1.44, 2.57) | <.0001* |
| No | 80.8/89.6 | Reference | |
| Hyperlipidemia | |||
| Yes | 20.0/6.6 | 3.32 (2.35, 4.70) | <.0001* |
| No | 80.0/93.4 | Reference |
OR odds ratio, CI confidence intervals, EOCRC early-onset colorectal cancer, LOCRC late-onset colorectal Cancer, % percentage
*Significance level was set at < 0.05
#Adjusted for sex, race, and marital status