Table 3.
Logistic regression comparing association between risk factors and age at CRC diagnosis (Late-Onset, LOCRC vs Early-Onset, EOCRC) by race
| Black patients (n = 861) | White patients (n = 2153) | ||||||
|---|---|---|---|---|---|---|---|
| Exposures | LOCRC/EOCRC (%) | Adjusted OR# (95% CI) | p-value | LOCRC/EOCRC (%) | Adjusted OR# (95% CI) | p-value | Interactionp-value |
| Lifestyle | |||||||
| Body mass index | 0.9626 | ||||||
| Underweight | 6.8/8.4 | 0.62 (0.30, 1.30) | 0.5211 | 5.5/5.2 | 0.80 (0.48, 1.34) | 0.8979 | |
| Overweight | 28.1/24.1 | 0.83 (0.49, 1.40) | 0.4605 | 32.5/30.0 | 0.90 (0.67, 1.21) | 0.3421 | |
| Obese | 35.8/47.4 | 0.56 (0.34, 0.90) | 0.0667 | 31.0/40.0 | 0.62 (0.47, 0.82) | 0.0052* | |
| Normal weight | 29.3/20.1 | Reference | 31.0/24.8 | Reference | |||
| Smoking status | 0.3908 | ||||||
| Current | 16.6/21.2 | 1.01 (0.62, 1.65) | 0.0722 | 15.3/16.9 | 1.14 (0.83, 1.57) | 0.3446 | |
| Former | 32.0/16.5 | 2.47 (1.51, 4.06) | 0.0003* | 37.3/25.1 | 1.75 (1.34, 2.28) | 0.0003* | |
| Never | 51.4/62.3 | Reference | 47.4/58.0 | Reference | |||
| Clinical | |||||||
| Hypertension | 0.0955 | ||||||
| Yes | 18.4/11.0 | 1.72 (1.00, 2.98) | 0.0520 | 10.0/2.9 | 3.43 (1.88, 6.24) | 0.0004* | |
| No | 81.6/89.0 | Reference | 90.0/97.1 | Reference | |||
| Type 2 diabetes | 0.7184 | ||||||
| Yes | 26.3/14.3 | 1.98 (1.03, 3.82) | 0.0405* | 16.8/9.5 | 2.67 (1.62, 4.40) | 0.0001* | |
| No | 73.4/85.7 | Reference | 83.2/90.5 | Reference | |||
| Hyperlipidemia | 0.2241 | ||||||
| Yes | 24.9/5.8 | 4.83 (2.40, 9.73) | < 0.0001* | 18.8/7.1 | 2.88 (1.93, 4.30) | < 0.0001* | |
| No | 75.1/94.2 | Reference | 81.2/92.9 | Reference | |||
OR odds ratio, CI confidence intervals, EOCRC early-onset colorectal cancer, LOCRC late-onset colorectal cancer, % percentage
*Significance level was set at < 0.05 for main effects and interaction effects
#Adjusted for sex and marital status