FIG. 9.

Schematic diagram of the core domain of RAG-1 (amino acids 384 to 1008) mapping the phenotypic classes of mutants identified in this study. The active-site residues, D600, D708, and E962, are shown as large white letters in green boxes. The nonamer-binding domain, zinc finger B, and coding flank region are also shown. Asterisks indicate two acidic residues previously identified as joining mutants (54). Arrows indicate mutants with corresponding mutants found in T⁻ B⁻ Scid and Omenn syndrome patients. The human mutations are R396C, R396L, or R396H; R404W; R410Q; R474H; R507W; R624H or R624C; R737H; H753L; R841W; R973H; R975Q; and K992E (7, 55, 66, 67).