Table 2.

Literature data for fitting or validation of the model

Data	Species	n	Study duration (days)	BW mean at study begin (kg)	Exposure	Exposure duration (days)	Fitted parameters	Matrix for fitting	Predicted matrix	Refs
Fitting	Male beef cattle	3	28	329	8000 μg/kg	Single bolus	ka, Fa, Jmaxinvivo, Km	Feces, urine	Plasma, liver, kidney, muscle	Lupton et al. (2014)
	Female dairy sheep	2	42	63	1.16 μg/kg/day 1.45 μg/kg/day	21	ka, Fa, Kmammary, Jmaxinvivoa, kma	Plasma, feces, milk	Liver, kidney, muscle	Kowalczyk et al. (2012)
	Male broiler chicken	6	231	1.5	0.085 μg/kg/day	102	ka, Jmaxinvivo, kma	Plasmab	–	Tarazona et al. (2015)
Validation	Male, female beef cattle	2–4	343	308	98 μg/kg 9090 μg/kg	Single bolus		–	Plasma, liver, kidney, muscle	Lupton et al. (2015)
	Non-dairy sheep	8	112	24	0.0208 μg/kg/day	56 or 112		–	Liver	Zafeiraki et al. (2016)
	Male laying chicken	12	42	0.04	100 or 1000 μg/kg/dose	21 (ten doses)		–	Blood, liver, kidney	Yeung et al. (2009)

^aSame as cattle

^bOriginally serum