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OM-RNA inhibition of telomerase uncovers different mechanisms for TRF1-LacI and TRF2-LacI effects. Graphical representation of TRF and ORTF variations in TRF1-LacI (A) and TRF2-LacI (B) cells treated with 1 μM PonA during successive transfections either with no oligonucleotide (Mock experiment) or with OM-RNA (+OM-RNA). The curves correspond to the linear regressions that were used to estimate the degradation rate of telomeric DNA (the boxed values are expressed in nucleotides/MPD).
