TABLE 1 ∣.
Respiratory morbidity and perinatal characteristics by supplemental oxygen status at hospital discharge.
| Oxygen group n = 8 | No oxygen n = 40 | p value** | |
|---|---|---|---|
| Age at data collection, months median [range] | 42 (12–92.7) | 12 (12–113.8) | 0.150 |
| A. Perinatal characteristics | |||
| Maternal diabetes n (%) | 2 (29)1 | 1 (6)2 | 0.194 |
| Antenatal steroids n (%) | 1 (12) | 5 (14)3 | 0.703 |
| Gestational age-weeks, median [range] | 35.5 [25–39] | 36 [25–40] | 0.569 |
| Cesarean delivery n (%) | 8 (100) | 19 (49) | 0.006 |
| Birth weight-kg median [range] | 2.6 [0.66–3.89] | 2.8 [0.72–3.94] | 0.558 |
| B. NICU respiratory morbidity | |||
| Surfactant n (%) | 8 (100) | 33 (82) | 0.583 |
| NICU diuretics n (%) | 3 (43)1 | 2 (5) | 0.019 |
| Systemic corticosteroids n (%) | 5 (62) | 3 (7) | 0.002 |
| Maximum respiratory support | 0.070 | ||
| ECMO n (%) | 1 (12) | 0 | |
| Intubation and mechanical ventilation n (%) | 6 (75) | 31 (77) | |
| NIPPV n (%) | 1 (12) | 9 (23) | |
| Prolonged rupture of membranes (PROM) | 01 | 5 (23)4 | 0.030 |
| +GBS | 01 | 2 (9)4 | 0.611 |
| Chorioamnionitis, +Blood culture | 01 | 04 | — |
| C. Respiratory morbidity after NICU discharge | |||
| Supplemental oxygen duration in months median [range] | 10.5 [1–28] | — | — |
| Amount of supplemental oxygen in LPM median [range] | 0.3 [0.1–0.6]1 | — | — |
| Chronic mechanical ventilation n (%) | 2 (25) | — | — |
| ≥ 2 courses of oral corticosteroids n (%) | 3 (43)1 | 3 (14)4 | 0.110 |
| Number of courses median [range] | 2 [1–5] | 2 [1–15] | |
| Inhaled corticosteroids n (%) | 4 (57)1 | 3 (75)5 | 1.000 |
| Hospitalizations n (%) | 5 (62) | 2 (8)6 | 0.005 |
| Number of hospitalizations median [range] | 1 [1–3] | 1 | |
| ED visit n (%) | 5 (71)1 | 8 (35)7 | 0.003 |
| Number of ED visits median [range] | 1 [1–2] | 1.5 [1–3] | |
| Tube feeds | 5 (71)1 | 2 (10)8 | 0.004 |
Note:
*
Data not available for the full study group
1
n = 7
2
n = 17
3
n = 36
4
n = 22
5
n = 4
6
n = 24
7
n = 23
8
n = 21.
**
p values obtained using Fisher's exact test and Chi-Square for categorical variants, and Wilcoxon Rank-Sum Test for continuous variables without correction for multiple comparisons.
Abbreviations: LPM = liters per minute.