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Model for the association and disruption of the BRCA1-c-Abl complex and its role. BRCA1 and c-Abl interact constitutively, and c-Abl tyrosine kinase activity is inhibited. After irradiation, ATM kinase is activated, phosphorylating BRCA1 and activating c-Abl, causing disruption of the complex. Consequently, the c-Abl tyrosine kinase activity is stimulated, leading to phosphorylation of a minor subset of BRCA1.
