TABLE 1.
Cardiac contractility in PP1-overexpressing mice characterized by in vivo echocardiographya
| Mouse type, age (mo) | n | Heart rate (beats/min) | LV EDD (mm) | LV ESD (mm) | FS (%) | Vcfc (circ/s) | LVM/body wt (mg/g) | h/r ratio | Body wt (g) |
|---|---|---|---|---|---|---|---|---|---|
| WT, 3 | 7 | 408 ± 34 | 3.44 ± 0.12 | 2.11 ± 0.19 | 39.1 ± 4.2 | 7.2 ± 0.9 | 2.00 ± 0.13 | 0.29 ± 0.02 | 19.2 ± 0.8 |
| PP1, 3 | 10 | 402 ± 15 | 3.80 ± 0.13 | 2.80 ± 0.14∗ | 26.5 ± 2.1∗ | 4.9 ± 0.5∗ | 2.40 ± 0.24 | 0.29 ± 0.02 | 18.9 ± 0.9 |
| WT, 6 | 12 | 410 ± 20 | 3.56 ± 0.12 | 2.11 ± 0.10 | 40.8 ± 2.2 | 7.0 ± 0.5 | 2.21 ± 0.12 | 0.33 ± 0.01 | 23.6 ± 1.0 |
| PP1, 6 | 10 | 345 ± 26 | 4.03 ± 0.19† | 3.10 ± 0.21† | 23.5 ± 2.0† | 4.3 ± 0.4† | 3.19 ± 0.27† | 0.32 ± 0.01 | 22.2 ± 0.9 |
a
Abbreviations: EDD, end-diastolic dimension; ESD, end-systolic dimension; LVM, calculated LV mass; h/r ratio, relative wall thickness, where h is wall thickness and r is LV radius. ∗, P < 0.05 versus the value for the WT at 3 months; †, P < 0.05 versus the value for the WT at 6 months.