Skip to main content
. 2026 Jul 8;13:1856132. doi: 10.3389/fmed.2026.1856132

Figure 2.

(a) Functional enrichment analysis of Day 4 DEGs in IMV versus non-IMV groups. Gene-term interaction networks show enriched biological processes. Downregulated genes (green: TFPI, PDGFRA, TNFAIP6, KREMEN1) were linked to negative regulation of response to external stimulus. IL-10 and CYP19A1 downregulation related to negative regulation of chronic inflammatory response. Response to carbon monoxide involved KCNMA1 upregulation (red) and IL-10 downregulation. Heatmap bar reflects log2 fold change. (b) Venn diagrams comparing Day 4 (green) and Day 8 (blue) DEGs, showing total, upregulated, and downregulated counts. Five DEGs overlapped: three upregulated (RNF165, KCNMA1, AC245014.3) and two downregulated (TFPI, MTARC2).

(a) Functional enrichment analysis of differentially expressed genes (DEGs) in IMV versus non-IMV groups at Day 4. Gene-term interaction networks highlight biological processes enriched among DEGs. Downregulated genes (green) included TFPI, PDGFRA, TNFAIP6, and KREMEN1, associated with negative regulation of response to external stimulus. Downregulation of IL-10 and CYP19A1 was linked to negative regulation of chronic inflammatory response. Response to carbon monoxide involved upregulation of KCNMA1 (red) and downregulation of IL-10. Heatmap bar indicates log2 fold change values. (b) Overlap of DEGs between Day 4 and Day 8 in IMV versus non-IMV groups. Venn diagrams show the number of total, upregulated, and downregulated DEGs (adjusted p < 0.05) identified at Day 4 (green) and Day 8 (blue). Five DEGs were shared between time points: three upregulated (RNF165, KCNMA1, AC245014.3) and two downregulated (TFPI, MTARC2).