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. 2026 May 20;16:22874. doi: 10.1038/s41598-026-52779-y

Table 2.

Summary of GWAS and MAGMA results for significant genes.

Gene Genomic positions (GRCh38) rsID Consequences Allele frequencies GWAS (AML_adjusted) SuSiE PIP LD- pruned status MAGMA (17 genes)§
gnomADg v.4.1 database thADg database# log (OR) (95% CI) P-value SNPs p-value FDR
BBS1

chr11:66524089:A: G

rs1791683

 Intron variant 0.65 0.57 8.78 (5.22,12.34) 0.00081 100.0% YES 5 0.002 0.020

chr11:66532992:G: A

rs1791686

 3 prime UTR variant 0.34 0.48 − 8.05 (− 11.6,− 4.5) 0.00206 33.13% –

chr11:66514067:A: G

rs1671062

 Intron variant 0.66 0.52 − 8.05 (− 11.6,− 4.5) 0.00206 33.13% YES

chr11:66532044:A: G

rs8432

 3 prime UTR variant 0.66 0.52 − 8.05 (− 11.6,− 4.5) 0.00206 33.13% –
C1QL2

chr2:119158737:T: A

rs2121217

 5 prime UTR variant 0.20 0.58 6.79 (3.97,9.61) 0.00106 22.81% – 2 0.001 0.020

chr2:119157933:G: T

rs1317848

 Synonymous variant 0.20 0.58 6.79 (3.97,9.61) 0.00106 22.81% YES
RSPH4A

chr6:116633023:T: C

rs784136

 Downstream gene variant 0.21 0.13 8.42 (5.21,11.62) 0.00036 10.90% – 6 0.001 0.020
RWDD1

chr6:116578159:C: G

rs7757967

 Intron variant 0.81 0.87 8.76 (5.35,12.16) 0.00047 21.14% – 8 0.001 0.020

chr6:116591572:A: C

rs4142086

 Intron variant 0.81 0.87 8.76 (5.35,12.16) 0.00047 21.14% –

chr6:116597448:G: A

rs1062353

 3 prime UTR variant 0.81 0.87 8.76 (5.35,12.16) 0.00047 9.37% –

chr6:116577253:A: C

rs7752566

 Intron variant 0.81 0.87 8.76 (5.35,12.16) 0.00047 21.14% YES

chr6:116580477:G: A

rs1321534

 intron variant 0.81 0.87 8.76 (5.35,12.16) 0.00047 21.14% –

chr6:116587423:G: A

rs4946184

 Intron variant 0.81 0.87 8.76 (5.35,12.16) 0.00047 21.14% –

chr6:116598041:T: G

rs6915260

 Downstream gene variant 0.81 0.87 8.76 (5.35,12.16) 0.00047 9.37% –

chr6:116602586:T: C

rs6912594

 Downstream gene variant 0.81 0.87 8.76 (5.35,12.16) 0.00047 9.37% –
TOM1L1

chr17:54923631:T: C

rs7224810

 Intron variant 0.99 0.73 7.15 (3.77,10.53) 0.00406 4.69% – 13 0.004 0.041

chr17:54921706:C: G

rs2958910

 Intron variant 0.98 0.73 7.17 (3.84,10.5) 0.00347 5.08% YES

chr17:54909364:A: G

rs4372751

 Intron variant 0.68 0.73 7.99 (4.59,11.39) 0.00141 8.04% YES

chr17:54946668:C: G

rs2908862

 Intron variant 0.99 0.80 7.95 (4.53,11.38) 0.00162 7.48% YES

chr17:54911699:A: T

rs7222890

 Intron variant 0.69 0.72 7.99 (4.59,11.39) 0.00141 8.04% –

chr17:54942935:A: G

rs2958947

 Intron variant 0.98 0.73 7.15 (3.77,10.53) 0.00406 4.69% –
TTC7B

chr14:90719101:C: A

rs10150862

 Intron variant 0.63 0.30 8.78 (5.59,11.97) 0.00018 4.84% – 95 0.001 0.020

chr14:90675084:A: G

rs12894664

 Intron variant 0.53 0.71 9.22 (5.9,12.54) 0.00016 5.12% YES

chr14:90675492:A: G

rs753310

 Intron variant 0.53 0.71 10.32 (6.85,13.79) 5.00E−05 6.55% –

chr14:90814720:G: A

rs1286305

 Intron variant 0.38 0.49 3.89 (1.51,6.26) 0.02603 4.52% –

chr14:90719154:C: T

rs12896077

 Intron variant 0.38 0.27 8.93 (5.66,12.19) 0.0002 5.33% –

chr14:90813113:A: C

rs1286306

 Intron variant 0.33 0.49 3.89 (1.51,6.26) 0.02603 4.52% YES

This table details variants within MAGMA-significant genes, including genomic positions, rsIDs, consequences, allele frequencies (gnomADg and thADg), GWAS statistics (log (OR), 95% CI, p-value), SuSiE posterior inclusion probabilities (PIP), LD-pruned status, and gene-level MAGMA p-values with FDR correction. Lead variants per gene are highlighted for clarity. Derived allele frequencies were obtained from the ThaiGeR database (https://thaiger.genomicsthailand.com). MAGMA p-values were FDR-corrected for multiple testing. Full details of the gene sets tested are provided in Supplementary Tables 1–2.