FIG. 8.

Immunoblot of various cadherins and catenins in protein extracts of cerebellum (A) and skeletal muscle (B) from wild-type and homozygous mouse mutants. The M-cadherin null mutation is confirmed by the complete absence of M-cadherin in homozygous animals. Concentrations of canonical catenins present in microfilament-anchoring adherens junctions appear largely unaffected by the mutation. N-cadherin is moderately upregulated (35 to 50%) in the cerebellum of M-cadherin null mutants. Note the very low level of N-cadherin present in nonregenerating adult skeletal muscle.