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Locations of the constitutively active MTK1 mutations. (A) The positions of the 11 MTK1 mutations are shown along a bar representing the MTK1 coding sequence. Four regions (A1, A2, B1, and B2) are indicated. The GADD45-binding domain and the kinase catalytic domain are also shown. (B) The predicted three-dimensional locations of the two mutations in region B2 (I1360M and M1414I) are shown by using the crystallographic structure of the PAK1 kinase domain (19).
