Skip to main content
. 2026 Jul 22;16(37):38950–39006. doi: 10.1039/d6ra01629d

Table 3. Screening of green polar aprotic solvents for the SNAr reaction of benzimidazole with bis(4-fluorophenyl) sulfone.

Entry Solvent Dielectric constant Isolated yield (%) HPLC purity (%)
1 B 28.3 91 98
2 PolarClean X 29.9 92 95
3 DMAc/toluene 37.8/2.4 70 N/A
4 PC 65.5 1 37
5 GVL 36.5 86 92
6 Cyrene 37.3 11 99